GLP1 Study

Participant Recruitment

Go To Application

The Kian Aesthetic Institute is recruiting qualified adults for a clinical study evaluating facial changes associated with the use of GLP-1 medications (such as semaglutide, liraglutide, and tirzepatide). The study includes in-office visits in Los Angeles. Enrollment is limited.

Submitting an application does not guarantee enrollment. Eligible candidates will be contacted for screening.

Who May Participate

This study follows the same general eligibility criteria as our previous research protocols, with clarifications specific to this GLP-1 study:

  • Participants must be on a stable dose of a GLP-1 or GIP/GLP-1 agonist medication (such as semaglutide, liraglutide, or tirzepatide) under the supervision of a healthcare provider for at least 3 months prior to enrollment.

  • Participants must maintain stable body weight (within ±5%) and continue their current medication regimen throughout the study period.

Study Overview

This study evaluates facial changes associated with GLP-1 use. Participation requires multiple in-office visits at Kian Aesthetic Institute in Los Angeles.

Enrollment is limited.

Inclusion Criteria

Adult 22–65 years old BMI 18.5–30 On stable GLP-1 / GIP-GLP-1 medication (semaglutide, liraglutide, or tirzepatide) ≥3 months At desired weight and stable (±5%) for ≥3 months Agrees to maintain weight (±5%) during study Meets required facial assessment scores (jawline, midface, neck, lines/folds) In good general health Not pregnant or breastfeeding Negative pregnancy test at screening (if applicable) Able to follow all visit requirements Willing to avoid direct / prolonged sun exposure to face & neck for duration of study

Exclusion Criteria

History of severe allergies / anaphylaxis Allergy to gram+ bacterial proteins or lidocaine Pregnant, nursing, or planning pregnancy Uncontrolled systemic / autoimmune disease Bleeding disorder or blood thinners Facial/neck surgery, permanent implants, fat grafting, or permanent fillers Filler, fat-reducing injectables, or toxin in face/neck within recent period Energy-based tightening / fat reduction to face or neck in past 6 months Recent resurfacing (laser, IPL, RF, microneedling, peel) to face/neck Marked facial asymmetry or excessively loose facial/neck skin Active infection, inflammation, or unhealed wound in treatment area History of keloid / hypertrophic scarring Active substance abuse (past 6 months) Currently in another investigational study Study staff, sponsor employees, or immediate family

Visit Schedule

V1
Screening + Baseline Photos + Assessment
V2
Follow-Up Imaging & Clinical Evaluation
V3
Midpoint Evaluation
V4
Final Imaging & Study Close

Note: Exact number and timing of visits may vary by subject. All visits are in-office.

Compensation

Qualified participants may receive compensation for each completed study visit.

All assessments and photography are provided at no cost.

Application Form

Complete the form linked below. Our research team will review your submission and contact eligible applicants to schedule screening.

What to Expect

• Screening will confirm eligibility, review informed consent, document medical history, and establish baseline photographs.

• All assessments are performed by or under the supervision of Dr. Kian Karimi.

• Standardized photography and clinical evaluations of facial contour, skin quality, and safety will occur at each visit.

• Participants must maintain their current GLP-1 medication, keep body weight stable (within ±5%), and avoid additional cosmetic procedures in the face and neck for the duration of the study.

• Direct sun exposure, tanning, or intentional UV exposure to the face and neck must be avoided during participation.

• Missed visits or unapproved outside treatments in the study area may affect eligibility to continue.